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. 1965 Sep;18(5):660–663. doi: 10.1136/jcp.18.5.660

Serum enzymes in diseases of the thyroid gland

P D Griffiths 1
PMCID: PMC473039  PMID: 5897412

Abstract

Serum enzyme assays have been carried out in 66 patients suffering from diseases of the thyroid gland. Sixty per cent. of the hypothyroid patients had increased levels of aldolase and glutamic oxaloacetic transaminase, and 90% had high activities of creatine kinase. The significance of these findings, especially with regard to creatine kinase, is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASKONAS B. A. Effect of thyroxine on creatinephosphokinase activity. Nature. 1951 Jun 9;167(4258):933–934. doi: 10.1038/167933a0. [DOI] [PubMed] [Google Scholar]
  2. BERTOLINI A. M., QUARTO DI PALO F. M. Effect of the thyroid gland and of glucose-1-phosphate upon the phosphocreatine metabolism of the heart. Acta Med Scand. 1956 Jan 25;153(4):329–332. doi: 10.1111/j.0954-6820.1955.tb18234.x. [DOI] [PubMed] [Google Scholar]
  3. BRUNS F. Bestimmung und Eigenschaften der Serumaldolase. Biochem Z. 1954;325(2):156–162. [PubMed] [Google Scholar]
  4. COMINGS D. E. Myxedema with Erb's limb girdle muscular dystrophy. Report of a case with a review of the muscular abnormalities of myxedema. Arch Intern Med. 1962 Jun;109:724–730. doi: 10.1001/archinte.1962.03620180086010. [DOI] [PubMed] [Google Scholar]
  5. DELLA SANTA L. [Serum transaminase activity in hypothyroid children]. Minerva Pediatr. 1962 Feb 11;14:136–140. [PubMed] [Google Scholar]
  6. DEUL D. H., VANBREEMEN J. F. ELECTROPHORESIS OF CREATINE PHOSPHOKINASE FROM VARIOUS ORGANS. Clin Chim Acta. 1964 Sep;10:276–283. doi: 10.1016/0009-8981(64)90147-0. [DOI] [PubMed] [Google Scholar]
  7. ENNOR A. H., ROSENBERG H. Some properties of creatine phosphokinase. Biochem J. 1954 Jun;57(2):203–212. doi: 10.1042/bj0570203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GRAIG F. A., ROSS G. Serum creatine-phosphokinase in thyroid disease. Metabolism. 1963 Jan;12:57–59. [PubMed] [Google Scholar]
  9. GRIFFITHS P. D. Creatinephosphokinase levels in hypothyroidism. Lancet. 1963 Apr 20;1(7286):894–894. doi: 10.1016/s0140-6736(63)91676-3. [DOI] [PubMed] [Google Scholar]
  10. GROB D. Myopathies and their relation to thyroid disease. N Y State J Med. 1963 Jan 15;63:218–228. [PubMed] [Google Scholar]
  11. HOCH F. L. Biochemical actions of thyroid hormones. Physiol Rev. 1962 Oct;42:605–673. doi: 10.1152/physrev.1962.42.4.605. [DOI] [PubMed] [Google Scholar]
  12. KUBY S. A., NODA L., LARDY H. A. Adenosinetriphosphate-creatine transphosphorylase. III. Kinetic studies. J Biol Chem. 1954 Sep;210(1):65–82. [PubMed] [Google Scholar]
  13. LIEBERTHAL A. S., BENSON S. G., KLITGAARD H. M. Serum malic dehydrogenase in thyroid disease. J Clin Endocrinol Metab. 1963 Feb;23:211–214. doi: 10.1210/jcem-23-2-211. [DOI] [PubMed] [Google Scholar]
  14. MADENBERG F., BYFIELD G. V., BAKER L. A. Occurrence of ascites in myxedema; report of two cases. AMA Arch Intern Med. 1954 May;93(5):787–795. doi: 10.1001/archinte.1954.00240290145013. [DOI] [PubMed] [Google Scholar]
  15. REITMAN S., FRANKEL S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957 Jul;28(1):56–63. doi: 10.1093/ajcp/28.1.56. [DOI] [PubMed] [Google Scholar]
  16. SIBLEY J. A., FLEISHER G. A. The clinical significance of serum aldolase. Proc Staff Meet Mayo Clin. 1954 Nov 10;29(23):591–603. [PubMed] [Google Scholar]
  17. SOLVONUK P. F., MCRAE S. C., COLLIER H. B. Creatine phosphokinase activity of mammalian erythrocytes. Can J Biochem Physiol. 1956 May;34(3):481–487. [PubMed] [Google Scholar]
  18. WADE A. F. A case of myotonia congenita with hypothyroidism. Br Med J. 1957 May 25;1(5029):1223–1224. doi: 10.1136/bmj.1.5029.1223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. WILKINSON J. H. Isoenzymes, with special reference to new enzyme tests in myocardial infarction. Proc R Soc Med. 1963 Mar;56:177–179. [PMC free article] [PubMed] [Google Scholar]
  20. den BAKKER P. B., SUNDERMEYER J. F., WENDT V. E., SALHANEY M., GUDBJARNASON S., BING R. J. Myocardial metabolism in a patient with Hashimoto's thyroiditis and hypothyroidism. Case report, with metabolic studies. Am J Med. 1962 May;32:822–826. doi: 10.1016/0002-9343(62)90173-0. [DOI] [PubMed] [Google Scholar]

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