Table 3.

The adjusted hazard ratios (HR) of risk factors for adverse events (AE) in multivariable analyses.

Characteristics	Overall AE			Liver Injury			Gastrointestinal Reactions
	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p
Region
East	1.33	0.97–1.83	0.07	1.91	1.35–2.71	< 0.01	0.34	0.19–0.62	<0.01
West	1.82	1.35–2.45	< 0.01	1.54	1.06–2.23	0.02	0.77	0.52–1.14	0.19
Center	ref			ref			ref
Age, years
≤18	–	–	–	1.50	0.75–3.00	0.25	–	–	–
40–59	–	–	–	0.79	0.57–1.08	0.14	–	–	–
≥60	–	–	–	0.50	0.32–0.80	< 0.01	–	–	–
19–39				ref
Sex (Male)	–	–		1.66	1.08–2.54	0.02	–	–	–
Education level	–	–		–	–	–	0.44	0.30–0.65	<0.01
Smoking status
ex-smokers	1.20	0.94–1.55	0.15	1.27	0.87–1.85	0.21	–	–	–
current smokers	1.64	1.23–2.18	< 0.01	1.71	1.12–2.59	0.01	–	–	–
never smokers	ref			ref
Symptom score	1.05	1.02–1.09	0.01	–	–	–	1.09	1.03–1.14	<0.01
TB Knowledge	0.69	0.60–0.81	< 0.01	0.79	0.65–0.97	0.02	0.66	0.52–0.84	<0.01