Table 1.
General characteristics of the family members in the household (n = 34) £.
| Variables | Number | Birth Year # | Skin Symptoms | Exposure Duration | Grade † | Pathological Examination |
|---|---|---|---|---|---|---|
| Generation I | A * | 1936 | Yes | 1973–1989 (16) | NA | NA |
| B | 1935 (NA) | Yes | 1973–1989 (16) § | Advanced | Bowen’s disease | |
| a * | 1941 | Yes | 1973–1989 (16) | NA | NA | |
| b | 1945 (1963) | Yes | 1973–1989 (16) | Advanced | Basal cell carcinoma | |
| Generation II | C | 1956 | Yes | 1973–1989 (16) | Advanced | Basal cell carcinoma |
| D | 1958 (1980) | Yes | 1980–1989 (9) | Mild | NA | |
| E | 1963 | Yes | 1973–1989 (16) | Advanced | Basal cell carcinoma | |
| F | 1965 (1990) | No | Non-exposed | |||
| G | 1966 | Yes | 1973–1989 (16) | Advanced | Basal cell carcinoma/Bowen’s disease | |
| H | 1969 (1991) | No | Non-exposed | |||
| I | 1972 | Yes | 1973–1989 (16) | Advanced | Basal cell carcinoma/Bowen’s disease | |
| J | 1976 (1996) | No | Non-exposed | |||
| K | 1970 | Yes | 1973–1989 (16) | Advanced | Bowen’s disease | |
| L $ | NA | No | Non-exposed | |||
| c | 1965 | Yes | 1973–1989 (16) | Advanced | Bowen’s disease | |
| d | 1970 (1989) | No | Non-exposed | |||
| e | 1970 | Yes | 1973–1989 (16) | Advanced | NA | |
| f | 1974 (1997) | No | Non-exposed | |||
| g | 1973 | Yes | 1973–1989 (16) | Advanced | Hyperkeratosis | |
| h | 1976 (2000) | No | Non-exposed | |||
| Generation III | M & | 1981 | Yes | 1981–1989 (8) | NA | NA |
| N | 1983 | Yes | 1983–1989 (6) | Mild | NA | |
| O | 1993 | No | Non-exposed | |||
| P | 1997 | No | Non-exposed | |||
| Q & | NA | No | Non-exposed § | |||
| R & | NA | No | Non-exposed § | |||
| S | 1998 | No | Non-exposed | |||
| T | 2004 | No | Non-exposed | |||
| U | 1996 | No | Non-exposed | |||
| V | 2001 | No | Non-exposed | |||
| i | 1990 | No | Non-exposed | |||
| j & | NA | No | Non-exposed § | |||
| k | 1998 | No | Non-exposed | |||
| m | 2004 | No | Non-exposed |
Notes: £: information on founding parents of the family is not included in the table because they died before 1973; *: family member deceased; &: family member works outside; #: the number in the bracket is the year that the family member moved into the household through marriage; $: this member is the husband of member K, and he has always lived in another village; §: the arsenic exposure status was confirmed based on the birth year of the next of kin.† Based on the diagnosis standard for endemic arsenicosis in China (WS/T211-2001), the grade of arsenicosis was determined by the clinical severities of skin pigmentation and de-pigmentation on the trunk and hyperkeratosis on the palms of the hands and soles of the feet; NA: not available.