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. Author manuscript; available in PMC: 2017 Jan 25.
Published in final edited form as: Dev Cell. 2016 Jan 25;36(2):139–151. doi: 10.1016/j.devcel.2015.12.019

Figure 2. XE14 encodes the Drosophila WAC homolog, wacky, a broadly-expressed protein with nuclear and lysosomal localization.

Figure 2

(A) Schematic representation of Wacky molecular lesions identified in XE14 alleles.

(B) Conservation of Wacky in humans and several model organisms.

(C) wacky cDNA constructs and genomic (gr) constructs, spanning the genomic region indicated, rescue wacky lethality. R, rescued.

(D) Immunofluorescence staining with FLAG antibody of wackyA rescued with 3xFLAG-2xHA-tagged genomic wacky transgene in the fat body of wandering L3 larvae. Scale bars are 20 μm.

See also Figure S2.