FIG 1.

Correlation bins for IL17F and IL17RA genes and flanking regions according to the 1000 Genomes YRI project (18). Pairwise R² values from comparisons of SNPs associated with CM in the two study populations (underlined SNPs) and SNPs in a 1-Mb region were determined with PLINK software (19). Polymorphisms belonging to the same correlation group or “bin” (R² > 0.6) are linked by a thick black line. (A) Chromosomal location of SNPs in the 6p region from 52.091 to 52.145 Mb that includes the IL17F gene (indicated by black vertical lines). The direction of gene transcription is indicated by the “<” sign. Correlation bins with R² of >0.6 are as follows: bin I, SNPs rs6913472, rs11465554, rs9474180, rs75748419, and rs17246675. (B) Chromosomal location of SNPs in the 22q region from 17.518 to 17.597 Mb that includes the IL17RA gene (indicated by black vertical lines). The direction of gene transcription is indicated by the “>” sign. Correlation bins with R² of >0.6 are as follows: bin I, rs12159217, rs13340087, rs13340086 and rs41436647; bin II, rs41396547 and 14 additional SNPs. The two SNPs whose designations are shown in parentheses, rs112979228 and rs41426844, were not informative and were excluded from the statistical analysis.