TABLE 5.
Results of combined analyses that included the case-control and familial dataa
| Analysis category | Gene | SNP | Minor allele/major allele | Risk allele | Freqb (risk) | OR (95% CI) | Pc |
|---|---|---|---|---|---|---|---|
| Univariate | IL17F | rs6913472 | A/G | A | 0.093 | 1.36 (1.06–1.97) | 0.059 |
| IL17RA | rs12159217 | T/G | G | 0.882 | 1.79 (1.24–2.52) | 0.001 | |
| rs41396547 | C/T | T | 0.956 | 3.17 (1.48–6.78) | 0.001 | ||
| rs41433045 | C/T | T | 0.973 | 4.12 (1.54–11.00) | 0.002 | ||
| Multivariated | IL17RA | rs12159217 | T/G | G | 0.882 | 3.40 (2.22–5.21) | <0.0001 |
| rs41396547 | C/T | T | 0.956 | 4.71 (1.99–11.17) | <0.0001 |
a
Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval; Freq, frequency.
b
Data represent risk allele frequencies.
c
All P values represent the results of 1-sided tests in reference to the risk allele.
d
Data represent results of multivariate analysis combining the four SNPs (rs6913472, rs12159217, rs41396547, and rs41433045).