TABLE 2.
ALL2 in acidic growth conditions regulates genes involved in transport and multiple pathways
| GO function and C. neoformans gene | Description | Fold change (mutant/wt) |
|---|---|---|
| Transport | ||
| CND02440 | Peptide transporter | 4.30 |
| CND00530 | Urea transporter | 3.70 |
| CND05980 | Nucleoside transporter | 3.40 |
| CNA07090 | ABC transporter | 2.60 |
| CNE00270 | Amino acid transmembrane transporter | 2.57 |
| CNA05800 | Amino acid transporter | 2.43 |
| CNB02200 | RAN protein binding protein | 2.27 |
| CNC05860 | Metal resistance protein | 2.10 |
| Nucleotide binding | ||
| CNN01260 | Plasma membrane H+-ATPase 1 | 9.50 |
| CNL04860 | ATPase activity | 2.70 |
| CND06300 | Aspartate-tRNA ligase | 2.23 |
| CNG01310 | Arginine-tRNA ligase | 2.23 |
| CNB05640 | Proline-tRNA ligase | 2.21 |
| CNF00070 | Glutamate-tRNA ligase | 2.02 |
| CNK00560 | DNA polymerase | 2.08 |
| CNM01290 | Leucine-tRNA ligase | 2.05 |
| CNN00350 | Glutamate-cysteine ligase | 2.03 |
| Transmembrane transport | ||
| CNC00060 | Sugar transporter | 3.07 |
| CND05980 | Folic acid metabolism | 2.92 |
| CND04690 | Sugar transporter | 2.90 |
| CNI03510 | Allanote transmembrane transporter | 2.88 |
| CNH01210 | Phosphate transmembrane transporter | 2.73 |
| CNC04510 | Siderophore (ion) uptake | 2.71 |
| CNG04630 | Efflux protein EncT | 2.64 |
| CNJ01450 | Multidrug transporter activity | 2.58 |
| CNE01880 | Pantothenate transporter | 2.57 |
| CNF01220 | Allantoate transmembrane transporter | 2.30 |
| CNF00350 | Hypothetical protein | 2.08 |
| CNG01480 | Fructose transmembrane transporter | 2.08 |
| CNC03220 | Receptor glucose binding | 2.07 |
| CNI03490 | Sugar transporter | 2.03 |
| CNC01890 | Na+/H+ exchange | 2.00 |
| CNE05340 | Allantoate membrane transporter | −4.01 |
| Catalytic activity | ||
| CNA02570 | Acetolactate synthase | 3.46 |
| CNG00590 | Folic acid metabolism | 2.92 |
| CNC00360 | Protein phosphatase | 2.83 |
| CNG01150 | Spermidine synthase | 2.78 |
| CNE00720 | Hypothetical protein | 2.46 |
| CNG04420 | α-1,3-Glucan synthase | 2.34 |
| CNN00440 | Purine nucleotide biosynthesis | 2.33 |
| CNA07740 | Acetate coligase | 2.28 |
| CNI03300 | Phosphoribosylformylglycinamidine synthase activity | 2.05 |
| CNB03190 | Hypothetical protein | 2.01 |
| CNE05320 | 5-Oxoprolinase | −2.10 |
| Glucogenesis | ||
| CNI03590 | Phosphoenolpyruvate carboxykinase, putative | 3.02 |
| CNJ00950 | Pyruvate decarboxylase | 2.35 |
| CNB04050 | Glucose 6-phosphate isomerase | 2.20 |
| Protein binding | ||
| CNG00480 | Atomer alpha subunit | 3.64 |
| CNG02370 | tRNA (guanine) methyltransferase | 3.28 |
| CNC02150 | Translation initiation factor | 2.92 |
| CNJ02300 | Structural molecule activity | 2.77 |
| CNH02560 | Hypothetical protein | 2.70 |
| CNG02820 | Protein phosphate regulator | 2.69 |
| CNE01020 | Translation initiation factor | 2.68 |
| CNB00260 | Hypothetical protein | 2.59 |
| CNN01950 | Hypothetical protein | 2.41 |
| CNJ01250 | Hypothetical protein | 2.39 |
| CNA04270 | HMG1 chromatin binding | 2.38 |
| CNA04050 | Elongation factor | 2.35 |
| CNK01990 | Hypothetical protein | 2.25 |
| CNB05570 | ER-to-Golgi body transport | 2.22 |
| CNJ00610 | Argonaute-like protein | 2.13 |
| CNJ00830 | Hypothetical protein | 2.13 |
| CNL05140 | Hypothetical protein | 2.13 |
| CNA04910 | Retrograde transport; endosome to Golgi body | 2.13 |
| CNB04960 | Hypothetical protein | 2.10 |
| CNK02410 | General transcription repressor | 2.10 |
| CNE03290 | Translation initiation factor | 2.10 |
| CNA00630 | Nuclear mRNA splicing | 2.07 |
| CNA06050 | Guanyl-nucleotide exchange factor | 2.01 |
| RNA binding | ||
| CNI01160 | Poly(A) binding | 4.01 |
| CNA01020 | Pre-mRNA splicing factor activity | 2.00 |
| CNE01200 | rRNA processing-related protein | 3.11 |
| CNC04280 | mRNA binding | 2.89 |
| CNE05380 | RNA-directed DNA polymerase activity | 2.10 |
| CNH03600 | Pseudouridine synthase | 2.35 |
| CNJ03440 | RNA-directed DNA polymerase activity | −2.04 |
| CNF04940 | RNA-directed DNA polymerase activity | −2.17 |