Table 6.
Top five significant hits, if any, of selected Cmap queries across microarray platforms and species
| Signatures | 1st match | 2nd match | 3rd match | 4th match | 5th match |
|---|---|---|---|---|---|
| From ZF 21K to ZF 43K (p-value = 0.026; signature size average = 181, min = 15, max = 375) | |||||
| EE2_30ngL_M_Brain_48hr.sig.500.IDswap | LIN_Embryo | PRO_F_Brain | LIN_Embryo | E2_M_Liver | FLU_Ovary |
| EE2_30ngL_M_Liver_48hr.sig.500.IDswap | E2_M_Liver | RDX_fry | RDX_fry | RDX_fry | PKC412_fish |
| EE2_30ngL_M_Testis_48hr.sig.500.IDswap | GEN_Embryo | BPA_Ovary | BPA_Embryo | BPA_Ovary | DBT_Embryo |
| FLU_Ovary_48hr.sig.500.IDswap | FLU_Embryo | PKC412_fish | BPA_Ovary | PPL_Embryo | RDX_fry |
| FLU_Testis_48hr.sig.500.IDswap | LIN_Embryo | LIN_Embryo | FLU_F_Ovary | PKC412_fish | FLU_Embryo |
| PRO_F_Brain_48hr.sig.500.IDswap | E2_M_Liver | PRO_F_Brain | GEN_Embryo | FLU_Embryo | PRO_Ovary |
| PRO_Ovary_48hr.sig.500.IDswap | PRO_Ovary | FLU_Ovary | PRO_F_Brain | ||
| PRO_Testis_48hr.sig.500.IDswap | E2_M_Liver | PRO_Ovary* | PRO_F_Brain* | ||
| From ZF 43K to ZF 21K (p-value = 0.022; signature size average = 134, min = 5, max = 310) | |||||
| E2_1uM_Embryo_4dpf.sig.500.IDswap | EE2_Testis | EE2_M_Liver | TRB_F_Liver | O2_Testis | O2_Ovary |
| E2_5ugL_M_Liver_4hrs.sig.500.IDswap | EE2_M_Liver | TRB_F_Liver | O2_Testis | O2_Testis | TCDD_Embryo |
| PRO_2mgL_Embryo_48hr.sig.500.IDswap | DMB_Embryo | tBHQ_Embryo | TRB_F_Brain | PRO_F_Brain | EE2_M_Liver |
| From ZF 21K to FHM 15K (p-value = 0.0076; signature size average = 124, min = 9, max = 257) | |||||
| EE2_30ngL_Ovary_96hr.sig.500.IDswap | FAD_Ovary | EE2_M_Brain | EE2_M_Brain* | ||
| EE2_30ngL_M_Liver_48hr.sig.500.IDswap | EE2_Liver | RochDS_liver | PHE_Liver | RochUS_liver | Stream_Liver |
| EE2_30ngL_Testis_48hr.sig.500.IDswap | PFCs_Liver | KTC_Ovary | PFCs_High_Liver | RochEFF_liver | |
| From FHM 15K to ZF 21K (p- value = 0.022; signature size average = 110, min = 5, max = 272) | |||||
| DES_100ngL_Liver_96h.sig.500.IDswap | EE2_M_Liver | DNP_Embryo | DMB_Embryo | TCDD_Embryo | APM_Embryo |
| E2a_4ugL_M_Liver_14d.sig.500.IDswap | EE2_M_Liver | KET_F_Liver | DNP_Embryo | KET_M_Liver | TRI_Ovary |
| EE2_25ngL_Liver_72h.sig.500.IDswap | EE2_M_Liver | KET_M_Liver | KET_F_Liver | TRB_F_Liver | FLU_M_Testis |
| From ZF 43K to FHM 15K (p-value = 0.0076; signature size average = 120, min = 6, max = 274) | |||||
| E2_M_Liver_4hrs.sig.500.IDswap | ElyEFF_liver | ElyDS_liver | PHE_Liver | E2_M_Liver | DES_Liver |
| GEN_Embryo_48hr.sig.500.IDswap | PFCs_Blood | KTC_Ovary | BIF_Larvae | E2_M_Liver | PER_Larvae |
| From FHM 15K to ZF 43K (p-value = 0.026; signature size average = 139, min = 5, max = 363) | |||||
| DES_1ngL_Liver_96h.sig.500.IDswap | E2_M_Liver | ||||
| E2_4ugL_M_Liver_14d.sig.500.IDswap | E2_M_Liver | PKC412_fish | BPA_Embryo | GEN_Embryo | BPA_Embryo |
| EE2_25ngL_Liver_72h.sig.500.IDswap | E2_M_Liver | PKC412_fish | LIN_Embryo | BPA_Embryo | BDE_Embryo |
Where similar signatures exist for a condition, only one of them is listed. ROGL hits are ranked by their adjusted connectivity scores and filtered by a p-value cutoff of 1/(number of sets of ROGLs). Informative connections, defined as a signature and one of its top five ROGL hits sharing the same or similar class of chemicals, are highlighted in bold. “*”, p-values slightly greater than the cutoffs