Fig. 2.

Treatment with ERCs significantly attenuates pathological damage induced by IRI in kidneys. Mouse kidneys were subjected to bilateral renal pedicles clipping for 30 min, then released and followed by 48 h reperfusion. Mice were sacrificed and the kidneys were harvested 48 h after reperfusion. a H&E staining was performed to evaluate renal pathological changes. The representative kidney sections of different groups were displayed. Magnification 100×. b Quantitative assessment of kidney damage was performed as described in the “Methods” section. Bar graphs represent mean ± SD of three separate experiments. p values were determined by one-way ANOVA. Data shown are representative of three separate experiments (*p < 0.05, vs. IRI-untreated group, n = 6)