Fig. 5.

ZnPP inhibited tumor angiogenesis in the HCT-15-induced tumor xenografts. a-b The mice were injected with PBS or 100 μg of ZnPP through tail vein three times (day 11, 13, and 16), and the angiogenesis fluorescent agent was injected for measuring the angiogenesis levels within tumors. The fluorescent intensity per square measure in the area of circle decreased by ~50 % in tumors treated with ZnPP compared to that treated with PBS. Tumors were indicated by circles. c-d The tumors from HCT-15-induced xenografts treated with PBS or ZnPP were investigated and compared using Western blots. The angiogenesis marker, αvβ3 integrin, decreased in the tumors treated with ZnPP compared to PBS by ~50 %. *p < 0.05