Fig. 3.

obASCs seeded on scaffolds display reduced osteogenesis in vivo. Critical size calvarial defects were created in the right parietal bone of nude mice. Treatment groups included defects without scaffold or cells (empty), defects with scaffold only and defects treated scaffolds seeded with lnASCs or obASCs. a Representative 3D reconstructions of microCT scans performed at 16 weeks. b Quantification of microCT. Scale bar represents 1 mm. Bars, ± SEM. ***, P < 0.001, compared to untreated defects; ^###, P < 0.001, compared between defects treated with scaffold and scaffolds seeded with lnASCs; ^ΦΦ, P < 0.01, compared between defects treated with scaffolds seeded with lnASCs and obASCs