Table 2.
Hazard ratios (95 % CIs) of cancer across quartiles of lysoPC a C18:0 and PC ae C30:0 concentrations
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ptrend (raw) | ptrend (corrected) | Measured in | ||
|---|---|---|---|---|---|---|---|---|
| LysoPC a C18:0 | 100 % | |||||||
| Breast cancer | Mediana | 13.52 | 17.34 | 20.36 | 23.23 | |||
| n cases | 137 | 96 | 84 | 45 | ||||
| Ref. | 0.63 (0.41, 0.97) | 0.65 (0.41, 1.02) | 0.29 (0.18, 0.47) | 0.00004 | 0.00421 | |||
| Prostate cancer | Median | 15.33 | 18.69 | 21.43 | 26.3 | |||
| n cases | 93 | 96 | 73 | 48 | ||||
| Ref. | 1.31 (0.75, 2.28) | 0.79 (0.45, 1.39) | 0.57 (0.33, 0.98) | 0.01388 | 1 | |||
| Colorectal cancer | Median | 14.37 | 17.71 | 21.21 | 24.13 | |||
| n cases | 47 | 47 | 46 | 23 | ||||
| Ref. | 1.16 (0.67, 2.01) | 1.06 (0.62, 1.82) | 0.50 (0.28, 0.90) | 0.00196 | 0.2348 | |||
| Overall cancer | Median | 14.37 | 17.93 | 20.85 | 24.63 | |||
| n cases | 280 | 228 | 211 | 116 | ||||
| Ref | 0.83 (0.61, 1.12) | 0.74 (0.55, 1.00) | 0.37 (0.27, 0.51) | 1.10 × 10−9 | 1.10 × 10−7 | |||
| PC ae C30:0 | 95.6 % | |||||||
| Breast cancer | Median | 0.33 | 0.40 | 0.47 | 0.60 | |||
| n cases | 69 | 74 | 92 | 113 | ||||
| Ref. | 1.08 (0.67, 1.75) | 1.45 (0.88, 2.37) | 1.97 (1.20, 3.23) | 0.00522 | 0.6260 | |||
| Prostate cancer | Median | 0.28 | 0.35 | 0.4 | 0.53 | |||
| n cases | 64 | 63 | 71 | 100 | ||||
| Ref. | 0.89 (0.50, 1.58) | 1.38 (0.78, 2.44) | 1.89 (1.06, 3.36) | 0.00194 | 0.2328 | |||
| Colorectal cancer | Median | 0.28 | 0.38 | 0.45 | 0.59 | |||
| n cases | 36 | 36 | 46 | 39 | ||||
| Ref | 1.00 (0.54, 1.83) | 1.79 (1.01, 3.18) | 1.84 (1.02, 3.34) | 0.01069 | 1 | |||
| Overall cancer | Median | 0.30 | 0.37 | 0.44 | 0.58 | |||
| n cases | 168 | 174 | 208 | 253 | ||||
| Ref | 1.03 (0.73, 1.45) | 1.41 (1.01, 1.96) | 1.85 (1.31, 2.60) | 0.00026 | 0.03137 |
Results from Cox proportional hazards regression analyses on pre-diagnostic metabolite concentrations and cancer risk over time. All multivariable Cox models were adjusted for age, smoking (never, former, current), lifetime alcohol intake (g/d), current aspirin use (yes/no), physical activity (Cambridge index), waist circumference (cm), BMI (continuous), height (cm), and education level (primary school, secondary school, university degree). Analyses on breast cancer risk were additionally adjusted for menopausal status, current HRT use (yes/no), current oral contraceptive use (yes/no), and at least one full term pregnancy (yes/no). Analyses on colorectal cancer risk were additionally adjusted for sex, fiber intake (g/d), and processed meat intake (g/d). aMedian metabolite concentrations in μmol/L