Table 1.
Summary of selected marker genes expression in the head as assessed by in situ hybridization
| Cranial sensory ganglia | Other PNS sites | |||||||
|---|---|---|---|---|---|---|---|---|
| Top | Tmm | VA | G | P | N | |||
| Trigeminal | DRG11 | +++ | +++ | - | - | - | - | |
| PRDM12 | +++ | +++ | - | + (distal) | + (distal) | + (distal) | Olfactory epithelium, ciliary ganglion, otic macular patches | |
| GAD2 | ++ | ++ | - | - | - | - | ||
| CHRNB4 | + | + | - | - | - | - | ||
| CHRNA3 | + | + | - | - | - | - | ||
| TOX2 | (+) | (+) | - | - | - | - | ||
| OTX2 | (+) | (+) | - | - | - | - | Ventral otic vesicle | |
| Vestibulo-acoustic | ESSRG | - | - | +++ | - | - | - | |
| PKDCCB | - | - | +++ | - | - | - | Otic macular patches | |
| LRRK1 | + (distal) | + (distal) | +++ | - | - | - | ||
| POU6F2 | + (distal) | + (distal) | +++ | - | - | - | ||
| RUNX1 | - | - | ++ | - | - | - | ||
| IRX2 | - | - | ++ | - | - | - | Otic vesicle | |
| FGF9 | - | - | ++ | - | - | - | ||
| SCN3A | + | + | +++ | + | + | + | Terminal nerve ganglion | |
| HMX3 | - | - | + | - | - | - | Dorsal otic vesicle | |
| Epibranchial | PHOX2B | - | - | - | +++ | +++ | +++ | Ciliary ganglion |
| PROX2 | - | - | - | ++ | ++ | ++ | Lens | |
| CTXN1 | - | - | - | +++ | +++ | +++ | ||
| SULT4A1 | + (distal) | + (distal) | + | +++ | +++ | +++ | Ciliary ganglion, terminal nerve ganglion | |
| PDZRN4 | - | - | - | ++ | ++ | ++ | ||
| SHOX2 | - | - | + | +++ | +++ | +++ | ||
| LHX4 | - | - | - | - | (+) | (+) | ||
| MECOM | - | - | - | - | - | - | ||
| PRRX1 | - | - | - | - | - | - | Medial otic vesicle | |
| PRRX2 | - | - | - | - | - | - | ||
Expression levels at stage HH21 are given for the cranial sensory ganglia (Top trigeminal ophthalmic, Tmm trigeminal maxillomandibular, VA vestibulo-acoustic, G geniculate, P petrosal, N nodose), as well as other sites in the PNS