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. 2015 Dec;10(12):2040–2047. doi: 10.4103/1673-5374.172324

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effect of the transplantation of hTERT-transfected Schwann cells at the site of injury on cell apoptosis (TUNEL assay, fluorescence microscope).

Specific brown particles were seen in the nuclei of apoptotic nerve cells (arrow; 200× magnification). Compared with the SCI group, the apoptotic rate was significantly (P < 0.05) less in both the Schwann cells without hTERT transfection group and the hTER-transfected group, with the latter group exhibiting the lowest rate (P < 0.05) (n = 5; paired comparison; one-way analysis of variance with the least significant difference test). hTERT: Human telomerase reverse transcriptase; SCI: spinal cord injury; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; SCs group: Schwann cells without hTERT transfection.