Table 1.
Anti-L. donovani Activity (IC50) and Cytotoxicity (CC50) against Mammalian Cells (Peritoneal Macrophages) of Metabolites 1−3
| compound | IC50 (μM) CI 95%
|
CC50 (μM) CI 95%
|
||
|---|---|---|---|---|
| promastigotes | amastigotes | mammalian cells | SI | |
| 1 | NA | 26.7 (13.8 to 31.7) | >293.8 | >11.0 |
| 2 | 111.8 (94.0 to 132.6) | 17.8 (15.3 to 20.8) | 111.2 (100.5 to 122.8) | 6.25 |
| 3 | NA | 101.9 (80.3 to 129.7) | >292.1 | >2.9 |
IC50: 50% inhibitory concentration; CC50: 50% cytotoxic concentration (mammalian cells); CI 95%: 95% confidence interval; SI: selectivity index (CC50 mammalian cells/IC50 Leishmania amastigotes); NA: not active. Sodium stibogluconate values:19 IC50 promastigotes (306.8 μM), amastigotes (13.3 μM); CC50 53.4 μM.