Table 2.

Spindle-assembly phenotypes of Aurora B perturbations in various species.

Species	Cell type	Perturbation	Phenotype
Zebrafish	Oocyte and early embryo	Hypomorphic survivin mutation	Assembly of bent spindles [134].
Xenopus laevis	Egg extract	CPC depletion	No spindles formed [18].
Mouse	Oocyte	Knockdown of INCENP	Spindles form normally, chromosome alignment defects [135].
		Chemical inhibition of Aurora B	Chromosome alignment defects [135]; chromosome alignment defects and spindle morphology defects [53].
	Early embryonic cells	Knockout of survivin	Spindle morphology defects [136].
		Knockout of INCENP	Multipolar spindles and other spindle morphology defects [137].
Human	HeLa cells	Knockdown of Survivin	Reduction in kinetochores that induce microtubule polymerisation following nocodazole washout [62].
Drosophila	Oocyte	Hypomorphic INCENP mutant	Meiosis I: Spindle formation delayed, multipolar spindles [50].
		RNAi of Aurora B or INCENP	No spindles formed [51].
	S2 cells	Artificially induced acentrosomal spindle assembly, RNAi of CPC subunits	Multipolar or small spindles [71].