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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e001359. doi: 10.1161/CIRCEP.115.001359

Figure 2.

Figure 2

Neurotrophins stimulate different effects in sympathetic neurons via activation of p75NTR and/or TrkA. Pro-Neurotrophins like ProNGF and ProBDNF are processed to mature neurotrophins (NGF, BDNF) by intra- and extra-cellular proteases. Activation of a p75NTR/Sortilin receptor complex by ProNGF or ProBDNF, or activation of p75NTR by BDNF, stimulates axon degeneration in sympathetic neurons. In contrast, NGF signaling via TrkA or a TrkA/p75NTR receptor complex stimulates sympathetic axon maintenance and growth.