Fig. 1.

Study time-line. Following baseline data acquisition, piglets underwent cerebral hypoxia–ischemia. At the end of hypoxia–ischemia (time 0), piglets were randomized to (i) Cooling (33.5 °C) for 24 h or (ii) Cooling + 50% Argon for 24 h. Treatment was started at 2 h after Time 0. Piglets were maintained under meticulous intensive care for 48 h following HI, prior to euthanasia. MRS was acquired at baseline, during HI, for the first 60 min after HI, at 24 and 48 h. EEG was acquired at baseline and in between the MRS acquisitions.