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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Invest Dermatol. 2016 Jan;136(1):161–172. doi: 10.1038/JID.2015.378

Figure 4. Psoriasis pathway enrichment scores.

Figure 4

(a) The enrichment of pivotal immune pathways of IL-17 and IFN-γ signaling was not different between Asian small, Asian intermediate, and Western large psoriasis. Negative regulator signaling in Western large psoriasis was downregulated compared to Asian intermediate psoriasis. (*p < 0.01 and FDR < 0.01) (b) Pathways involved in psoriasis comorbidities (psoriatic arthritis, cardiovascular disease, and atherosclerosis) were significantly enriched only in Western large psoriasis (p < 0.001 and FDR < 0.001). The scores were generated by GSVA with the combined z-score method. Gene sets for pathway analysis were curated from published papers (Belasco et al., 2014; Chiricozzi et al., 2014), Molecular signatures database (http://www.broadinstitute.org/gsea/msigdb), and Gene ontology consortium (http://geneontology.org).