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. Author manuscript; available in PMC: 2016 Feb 3.
Published in final edited form as: Biochemistry. 2015 Jan 17;54(4):1043–1052. doi: 10.1021/bi501350j

Figure 7. Proposed model for succinate oxidation and fumarate release.

Figure 7

(1) Succinate binds to the enzyme to induce conformational change from the “free” to the “occupied” form. (2) Succinate is oxidized, and FAD is reduced to FADH−. (3) The high energy “occupied”/FADH− transition state drives the conformational change to the “free” form. (4) Fumarate is released from the “free” form, and electrons are passed to SdhB.