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. Author manuscript; available in PMC: 2016 Jan 28.
Published in final edited form as: Exp Neurol. 2014 Mar 25;256:7–16. doi: 10.1016/j.expneurol.2014.03.008

Fig 6. MK-886 mitigates FPI-induced impairments in memory and learning in radial arms water maze.

Fig 6

(A) Day 1 learning task. The average number of errors (mean +/− SEM) made during the indicated swims in sham rats treated with either vehicle (black circles, n=8) or MK-886 (open circles, n=8) and in FPI-injured rats treated with either vehicle (grey squares, n=9) or MK-886 (green squares, n=8) 30 minutes after injury. There were no significant differences in initial learning curves (one-way repeated measures ANOVA) and no differences between groups at any swim time point for each three-swim cluster (one-way ANOVA). (B) Day 2 reversal task perseverance. The change in perseverance (duration in previous goal arm) at swim 3 expressed as the percentage of perseverance in swim 1. *p<0.05, **p<0.01, within-subjects two-way repeated measures ANOVA followed by paired student's t-test. (C) Day 2 post-perseverance reversal task performance. Errors (mean +/− SEM) made in swims 11-15 of the reversal task. *p<0.05, **p<0.01, different from FPI vehicle, no difference from either sham group, one-way ANOVA followed by Tukey's HSD.