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. Author manuscript; available in PMC: 2016 Jan 28.
Published in final edited form as: Austin J Pharmacol Ther. 2015 May 4;3(2):1069.

Table 2.

Small Molecule Screens with Zebrafish Cancer Models.

Cancer Type Zebrafish Model Compound Library Name Small Molecules
Identified		 References
Leukemia lck:EGFP ChemBridge DIVERSet Lenaldekar (LDK) [73]
T-ALL rag2:MYC-ER;mitf1a:mitf1a; rag2:dsRed2 Prestwick Chemical Library Spectrum Collection Phenothiazine [74]
T-ALL rag2:EGFP-mMyc;CG2 Compounds obtained from Sigma Aldrich Vincristine and Cyclophosphamide [75]
AML Xenotransplantation of K562, K562-R, JURKAT, NB4 human leukemia cell lines into wild-type zebrafish Imatinib, all-trans retinoic, mafosamide, cyclopjosphamide, 4EGI-1 Imatinib [76]
ALDH+ myelogenous leukemia Xenotransplantation of ALDH+ and ALDH− leukemia cells into fli1:EGFP;Casper imatinib, dasatinib, parthenolide, TDZD-8, arsenic trioxide, niclosamide, salinomycin, and thioridazine Imatinib [77]
AML Hsp70:AML1-ETO SPECTRUM library Microsource Discovery Systems Nimesulide [48]
Melanoma mitfa:BRAF(V600E); p53 −/− SPECTRUM library Microsource Discovery Systems Leflunomide [46]
Pancreatic Cancer Morpholinos and chemical screens selective RAR antagonists RAR antagonist Ro-41-5253 [93]
Human Carcinoma Xenotransplantation of YD10B and HSC-2 human oral squamous carcinoma cell lines; DLD-1 and HCT116 human colorectal carcinoma cell lines into wild-type zebrafish Tagged triazine molecules BII-B9 Paclitaxel [94]