Table 1.
Baseline Characteristics
| Sotalol (n = 24) |
Dofetilide (n= 15) |
|||
|---|---|---|---|---|
| Cases | Controls | Cases | Controls | |
| n | 8 | 16 | 5 | 10 |
| Age, years (±SD) | 60.3 (14.5) | 61.4 (14.0) | 68.4 (5.5) | 68.0 (5.4) |
| Women, n (%) | 6 (75%) | 12 (75%) | 4 (80%) | 8 (80%) |
| Ejection Fraction, % (±SD) | 43.1 (18.2) | 52.0 (11.5) | 48.0 (14.5) | 68.7 (18.2) |
| Mean drug dose before event/discharge (±SD) | 95(19.4) | 104.6(26.1) | 375(158.1) | 400(122.5) |
| Index rhythm, n (%) | ||||
| Atrial Fibrillation | 2 (25%) | 6 (37.5%) | 4 (80%) | 5 (50 %) |
| Atrial Flutter | 3 (37.5%) | 1 (6.25%) | 1 (20%) | 1 (10 %) |
| Sinus Rhythm | 3 (37.5%) | 5 (31.25%) | 0 (0%) | 4 (40%) |
| Rhythm before event | ||||
| Sinus Rhythm | 8 (100%) | - | 5 (100%) | - |
| Time to event/discharge, days (±SD) | 3.1 (1.8) | 2.6(0.7) | 3.3(2.3) | 2.2(0.4) |
| Time from analyzed ECG to Tdp, mins (range) | 113.5 (13-207) | 199.3 (9-568) | ||
| Lab values, (±SD) | ||||
| Potassium, mmol/L | 4.2 (0.5) | 4.2 (0.3) | 4.4 (0.4) | 4.2 (0.3) |
| Magnesium, mg/dL | 2.0 (0.3) | 2.0 (0.2) | 2.0 (0.2) | 2.0 (0.2) |
| Medications (%) | ||||
| Beta Blockers | 3 (37.5%) | 7 (43.75%) | 1 (20%) | 5 (50%) |
| ACE inhibitors | 1 (12.5%) | 7 (43.75%) | 1 (20%) | 5 (50%) |
| Calcium Channel Blocker | 1 (12.5%) | 2 (25%) | 0 (0%) | 3 (33.3%) |
| Digoxin | 1 (12.5%) | 1 (6.25%) | 2 (40%) | 1 (10%) |
| Thiazide Diuretic | 1 (12.5%) | 0 (0%) | 0 (0%) | 4 (40%) |
| Loop Diuretic | 3 (37.5%) | 5 (31.3%) | 4 (26.7%) | 3 (33.3%) |