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. 2016 Jan 28;11(1):e0146488. doi: 10.1371/journal.pone.0146488

Table 2. Treatment incidences (min-max) based on the animal unit dose (UD; TIUD) and prescribed daily dose (UDD; TIUDD) of the topical antimicrobial drugs in the different herd types.

Active substance ATCveta Indication UD (mg) Dairy herds Beef herds
Intramammary drugs TIUD TIUDD TIUD TIUDD
Procaine penicillin+ neomycin QJ51RC Md 500 0.07 0.03 - -
(0.00–0.43) (0.00–0.22)
Cloxacillin QJ51CF M 100 0.23 0.06 - -
(0.00–1.14) (0.00–0.31)
Cloxacillin QJ51CF De 2200 0.55 0.55 - -
(0.00–1.11) (0.00–1.11)
Nafcillin+benzylpenicillin+DHSb NAc M 100 0.59 0.45 0.06 0.06g
(0.00–1.42) (0.00–1.21) (0.00–0.49) (0.00–0.49)
Nafcillin+benzylpenicillin+DHS NA D 400 0.24 0.24 - -
(0.00–1.22) (0.00–1.22)
Cefquinome QJ51DA M 150 0.43 0.60 - -
(0.00–1.02) (0.00–0.97)
Cefalexin QJ51DA M 400 0.35 0.39 - -
(0.00–2.05) (0.00–2.31)
Lincomycin+neomycin QJ51RF M 660 0.17 0.29 0.03 0.03g
(0.00–0.43) (0.00–0.71) (0.00–0.30) (0.00–0.30)
Pirlimycin QJ51FF M 50 0.21 0.10 - -
(0.00–1.03) (0.00–0.51)
Total 2.83 2.71 0.09 0.09
(1.81–3.70) (0.94–3.83) (0.00–0.79) (0.00–0.79)
Intra-uterine drugs
Cefapirin QG01DA Vf 500 0.17 0.16 <0.01 <0.01
(0.00–0.78) (0.00–0.77) (0.0–0.02) (0.0–0.02)
Chlortetracycline hydrochloride QG01AA V 1500 0.25 0.16 0.78 1.07
(0.00–0.52) (0.00–0.34) (0.36–1.08) (0.39–1.62)
Total 0.42 0.32 0.78 1.07
(0.00–1.27) (0.00–1.11) (0.38–1.08) (0.39–1.62)
Grand total topical use 3.25 3.03 0.87 1.16

aAnatomical Therapeutic Chemical classification system for Veterinary medicinal products

bdihydrostreptomycin

cnot available

dM: mastitis

eD: dry cow therapy

fV: variable (prophylactic and/or therapeutic)

g TIUD values were used to calculate the total TIUDD