Table 4. Significant genotypic associations detected.
| N(%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP# ID | Gene | Alleles (1/2) | Subgroup | N | Model | 1/1 | 1/2+2/2 | P-value unadja | PFDRb | OR (95%CI) |
| rs12983082 | LDLR | C/T | Controls | 557 | 103 (21.3) | 380 (78.7) | ||||
| aPLA+ | 190 | Recessive | 61 (37.2) | 103 (62.8) | 6.71 x 10−5 | 2.55 x 10−3 | 2.18 (1.49–3.21) | |||
| aPLA+/th+ | 90 | Recessive | 30 (38.9) | 47 (61.0) | 9.33 x 10−4 | 0.0354 | 2.35 (1.42–3.91) | |||
| aPLA+/th- | 100 | Recessive | 31 (35.6) | 56 (64.4) | 4.27 x 10−3 | 0.1271 | 2.04 (1.25–3.33) | |||
| aPLA+/th+ vs aPLA+/th-c | 90 | Recessive | 30 (38.9) | 47 (61.0) | 0.6599 | 1 | 1.15 (0.61–2.17) | |||
| rs1003723 | LDLR | T/C | Controls | 557 | 117 (22.6) | 400 (77.4) | ||||
| aPLA+ | 190 | Recessive | 58 (36.5) | 101 (63.5) | 5.56 x 10−4 | 0.0106 | 1.96 (1.34–2.88) | |||
| aPLA+/th+ | 90 | Recessive | 27 (36.5) | 47 (63.5) | 9.33 x 10−4 | 0.1610 | 1.96 (1.17–3.29) | |||
| aPLA+/th- | 100 | Recessive | 31 (36.5) | 54 (63.5) | 6.69 x 10−3 | 0.1271 | 1.96 (1.20–3.19) | |||
| aPLA+/th+ vs aPLA+/th-c | 90 | Recessive | n.d. | n.d. | ||||||
| rs562556 | PCSK9 | A/G | Controls | 557 | 189 (34.9) | 352 (65.1) | ||||
| aPLA+ | 190 | Dominant | 77 (43.3) | 101 (56.7) | 4.65 x 10−2 | 0.2947 | 1.42 (1.05–2.00) | |||
| aPLA+/th+ | 90 | Dominant | 43 (51.8) | 40 (48.2) | 3.46 x 10−3 | 0.1315 | 2.00 (1.26–3.19) | |||
| aPLA+/th- | 100 | Dominant | 34 (35.8) | 61 (64.2) | 0.8722 | 0.9969 | 1.04 (0.65–1.64) | |||
| aPLA+/th+ vs aPLA+/th-c | 90 | Dominant | 43 (51.8) | 40 (48.2) | 3.22 x 10−2 | 0.7766 | 1.92 (1.06–3.52) | |||
a Logistic regression.
b P-values adjusted using FDR [40] Significant P-values in bold.
c Comparison of aPLA+/th+ (N = 90) with aPLA+/th- (N = 100).
* Allele combinations under recessive model. In Dominant model (rs562556), 1/1 genotype includes homozygotes for allele 2 and 1/2+2/2 column includes the heterozygote plus allele 1 homozygote. n.d, no data.