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. 2016 Jan 28;11(1):e0148169. doi: 10.1371/journal.pone.0148169

Fig 11. POm E-stimulation before whisker stimulus does not decrease cortical response magnitude and duration when PTX is applied in L1.

Fig 11

Raster plots and PSTHs are shown for a supragranular neuron before (A) and after (B) GABAergic inhibitory inactivation in L1. Before PTX application, sensory response (filled arrows) of this example neuron was abolished by POm E-stimulation before whisker stimulus. However, POm E-stimulation did not reduce sensory response when GABAergic inhibitory transmission in L1 was inactivated (B). GABAergic inactivation in L1 allowed POm E-stimulation to cause rebound spikes (in yellow). PTX effect is also shown in the sensory response (arrowheads) enlargement after PTX application. Control condition before (orange) and after (green) POm E-stimulation condition (blue) are shown. POm E-stimulation was applied 500 ms before pulses (air puffs) 11 to 20. Open arrows indicate orthodromic spikes elicited by POm E-stimulation. * indicates stimulation artifacts.