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. 2015 Dec 21;126(2):560–570. doi: 10.1172/JCI79197

Figure 4. Age- and dose-dependent loss of muscle mass in SDN mice.

Figure 4

(A) Body weight and (B) body composition were assessed in young adult (18-week-old) and older (58-week-old) SNARK transgenic mice and wild-type littermates (Control). DEXA, dual-energy X-ray absorptiometry. (C) The gastrocnemius/plantaris and (D) TA muscle complexes were weighed, and (E) forelimb grip strength was measured. For all panels, n = 20 for control, n = 13 for SDN-Low, n = 14 for SDN-High, n = 15 for SWT. *P < 0.05 vs. control of the same age group determined by 1-way ANOVA and Bonferroni post-hoc testing. Error bars indicate mean ± SEM.