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. 2015 Dec 21;126(2):571–584. doi: 10.1172/JCI77250

Figure 6. PlGF activates the LT pathway.

Figure 6

(A) The relative Alox5 mRNA expression in the lungs of Plgf+/+ and Plgf–/– BALB/c mice 48 hours after the last i.t. HDM exposure. *P < 0.05, **P < 0.01 by ANOVA (Bonferroni). (B) IHC showing 5-LO staining in lungs of saline and HDM-exposed Plgf+/+ and Plgf–/– BALB/c mice; magnification ×50. (C) CysLT levels in Plgf+/+ and Plgf–/– BALB/c mice measured in urine collected 24 hours after the last HDM exposure. (D) Cysltr1 mRNA expression in the lungs of HDM-exposed Plgf+/+ and Plgf–/– BALB/c mice. *P < 0.05 by Mann Whitney U test. All data are presented as mean ± SEM. Results are representative of 1 experiment (A, B, and D) and from 2 independent experiments (C).