Table 3. Relationship between EV-protein level and heart failure with reduced ejection fraction (HFREF) or heart failure with preserved ejection fraction (HFPEF) each compared to patients without heart failure (control).

Multivariable analysis	HFREF vs. control		HFPEF vs. control		HFREF vs. HFPEF		Multivariable analysis	HFREF vs. control			HFPEF vs. control			Multivariable analysis	HFREF vs. HFPEF
	OR	p-value	OR	p-value	OR	p-value		OR	p-value	95%CI	OR	p-value	95%CI		OR	p-value	95%CI
Cystatin C							Cystatin C							Cystatin C
TEX	1.46*	0.01	1.20*	0.32	0.955	0.81	TEX	1.58	0.056	(0.99–2.52)	1.23	0.596	(0.58–2.60)	TEX	1.15	0.830	(0.32–4.12)
LDL	1.32†	0.06	1.40*	0.06	1.214	0.46	LDL	1.38	0.117	(0.92–2.07)	0.99	0.985	(0.48–2.06)	LDL	1.29	0.748	(0.27–6.11)
HDL	1.40*	0.02	1.31*	0.09	1.314	0.32	HDL	1.50	0.034	(1.03–2.18)	1.13	0.727	(0.57–2.22)	HDL	1.55	0.501	(0.43–5.58)
CD14							CD14							CD14
TEX	1.03‡	0.83	1.21*	0.35	1.464	0.15	TEX	1.03	0.912	(0.65–1.61)	1.46	0.257	(0.76–2.8)	TEX	0.39	0.088	(0.14–1.15)
LDL	0.82‡	0.21	1.58*	0.01	2.246	0.00	LDL	0.90	0.641	(0.59–1.38)	1.41	0.245	(0.79–2.53)	LDL	0.29	0.062	(0.08–1.07)
HDL	1.37‡	0.05	2.29*	0.00	1.874	0.02	HDL	1.56	0.038	(1.03–2.38)	1.94	0.096	(0.89–4.25)	HDL	0.65	0.412	(0.24–1.80)
Serpin F2							Serpin F2							Serpin F2
TEX	0.82‡	0.19	1.04*	0.84	1.315	0.24	TEX	0.70	0.104	(0.45–1.08)	1.07	0.834	(0.56–2.05)	TEX	0.70	0.453	(0.28–1.76)
LDL	0.66‡	0.01	1.04*	0.87	1.645	0.05	LDL	0.62	0.029	(0.4–0.95)	1.10	0.762	(0.59–2.08)	LDL	0.60	0.223	(0.26–1.37)
HDL	0.86‡	0.31	1.70*	0.01	2.185	0.00	HDL	0.85	0.431	(0.58–1.26)	1.76	0.037	(1.04–2.99)	HDL	0.42	0.048	(0.18–0.99)
Serpin G1							Serpin G1							Serpin G1
TEX	1.37‡	0.04	1.31*	0.21	0.985	0.94	TEX	1.40	0.083	(0.96–2.03)	1.04	0.925	(0.45–2.43)	TEX	1.96	0.414	(0.39–9.91)
LDL	0.94‡	0.67	0.24*	0.01	0.514	0.19	LDL	0.84	0.506	(0.50–1.40)	0.12	0.034	(0.02–0.85)	LDL	2.66	0.410	(0.26–27.18)
HDL	0.96*	0.77	0.94*	0.77	1.005	0.98	HDL	1.23	0.298	(0.83–1.82)	0.77	0.535	(0.35–1.74)	HDL	1.76	0.359	(0.52–5.94)