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Comparison of IgG2a anti-DNA activation of RF B cells and DNA/IgM DVD-Ig activation of polyclonal B cells. Activation of both IgG2a-reactive RF B cells by an IgG2a anti-DNA autoantibody, and activation of polyclonal B cells by a DNA/IgM DVD-Ig, depends on co-engagement of the BCR and TLR9. The BCR delivers both kinds of immune complexes to TLR9 (purple receptor) inside an endosome (light grey circle).
