Fig. 1.

rOv-ASP-1 enhances antibody response to TIV in aged mice. Aged B6 mice were immunized i.m. with TIV alone (0.6 μg or 3 μg/mouse), or 0.6 μg or 3 μg TIV admixed with rOv-ASP-1 (TIV + ASP), or 0.6 μg TIV with alum (0.4 mg/mouse). As controls, young adult B6 mice were immunized i.m. with 3 μg TIV alone (3 μg TIV), or 3 μg TIV admixed with rOv-ASP-1 (3 μg TIV + ASP). Three weeks after immunization, influenza-specific IgG levels were determined in plasma using ELISA. Pooled data represent 9–13 mice in each group from 2 to 3 experiments. * p < 0.05.