Table 2.
Univariate and Multivariable predictors for neutropenia in the first year after LT
| Characteristic | Univariate | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age at transplant (in decades) | 1.00 (0.98, 1.02) | 0.83 | -- | -- |
| Male gender | 0.75 (0.47, 1.20) | 0.23 | -- | -- |
| White race | 0.80 (0.43, 1.48) | 0.48 | -- | -- |
| Late Era LT (2004–2009) | 2.18 (1.38, 3.45) | 0.001 | 2.28 (1.43, 3.65) | <0.001 |
| Comorbidities | ||||
| Coronary artery disease | 0.66 (0.33, 1.32) | 0.24 | -- | -- |
| eGFR at pre-LT baseline* | 0.995 (0.990,1.001) | 0.13 | -- | -- |
| Diabetes mellitus | 0.90 (0.52, 1.55) | 0.70 | -- | -- |
| Underlying Liver Disease | ||||
| Viral hepatitis | 0.85 (0.53, 1.35) | 0.48 | -- | -- |
| Hepatocellular carcinoma | 0.84 (0.49, 1.45) | 0.54 | -- | -- |
| Alcohol | 1.12 (0.69, 1.83) | 0.64 | -- | -- |
| Primary biliary cirrhosis | 1.45 (0.70, 3.03) | 0.32 | -- | -- |
| Primary sclerosing cholangitis | 0.73 (0.34, 1.60) | 0.44 | -- | -- |
| Autoimmune hepatitis | 1.39 (0.44, 4.42) | 0.58 | -- | -- |
| Status 1 | 1.44 (0.66, 3.14) | 0.36 | -- | -- |
| MELD score | 1.03 (1.01, 1.05) | 0.008 | -- | -- |
| CTP score | 1.14 (1.02, 1.30) | 0.02 | 1.15 (1.03, 1.30) | 0.02 |
| DRI | 1.28 (0.70, 2.31) | 0.43 | -- | -- |
| Pre-LT baseline ANC | 0.94 (0.86, 1.03) | 0.19 | -- | -- |
| Pre-LT baseline WBC | 0.94 (0.87, 1.02) | 0.13 | -- | -- |
| Living related donor | 0.66 (0.30, 1.44) | 0.30 | -- | -- |
| ATG for induction | 2.60 (1.33, 5.07) | 0.005 | -- | -- |
| Valganciclovir for CMV prophylaxis | 1.64 (1.00, 2.65) | 0.05 | -- | -- |
| Initial Immunosuppression | ||||
| MMF-based (reference) | -- | -- | -- | -- |
| AZA-based | 0.89 (0.40, 1.96) | 0.77 | -- | -- |
| Neither | 2.21 (1.27, 3.84) | 0.005 | -- | -- |
| Tacrolimus baseline trough level** | 1.02 (1.01, 1.03) | 0.001 | 1.02 (1.01, 1.03) | 0.007 |
| ATG for rejection | 1.07 (0.97, 1.18) | 0.20 | -- | -- |
| Methylprednisolone for rejection | 0.99 (0.90, 1.10) | 0.85 | -- | -- |
| Rejection | 0.86 (0.51, 1.47) | 0.59 | -- | -- |
| Invasive fungal infection | 1.91 (0.91, 4.02) | 0.09 | -- | -- |
| Blood stream infection | 2.78 (1.58, 4.89) | <0.001 | 2.89 (1.63, 5.11) | <0.001 |
| CMV disease | 5.36 (1.99, 14.42) | <0.001 | 4.28 (1.55, 11.81) | 0.005 |
eGFR calculated using CKD-EPI equation (20).
Baseline trough level is defined at time of discharge from transplant hospitalization.
The following variables were treated as time-dependent covariates: rejection, IFI, BSI, CMV disease, ATG for rejection, methylprednisolone for rejection. All variables with a p-value ≤ 0.10 on univariate testing were entered into the multivariable model.
Abbreviations: LT, liver transplantation; eGFR, estimated glomerular filtration rate; MELD, Model for End Stage Liver Disease; CTP, Child-Turcotte-Pugh; DRI, Donor Risk Index; ANC, absolute neutrophil count; WBC, white blood cell; CMV, cytomegalovirus; ATG, antithymocyte globulin; MMF, Mycophenolate mofetil; AZA, azathioprine.