Table 1.
Top results from the prespecified gene set analysis showing all associations with a nominal P < 0.05
| Gene/set | Annotation/frequency category | Variants in affected/unaffected | OR | P-value | P-value (adjusted) |
|---|---|---|---|---|---|
| Cav2 adaptors | Damaging/mac1 | 22/11 | 2.58 | 0.0008 | 0.049 |
| Neuronal synaptic vesicle | Lof/maf05 | 10/3 | 4.30 | 0.0171 | 0.780 |
| Cav2 adaptors | Damaging/maf05 | 41/35 | 1.51 | 0.0174 | 0.785 |
| Neuronal synaptic vesicle | Lof/maf01 | 10/3 | 4.30 | 0.0187 | 0.801 |
| Neuronal PSD | Lof/mac1 | 32/32 | 1.29 | 0.0211 | 0.834 |
| Cav2 adaptors | Damaging/maf01 | 32/25 | 1.65 | 0.0221 | 0.843 |
| Neuronal synaptic vesicle | Lof/mac1 | 8/3 | 3.44 | 0.0224 | 0.848 |
| Neuronal early endosomes | Damaging/mac1 | 4/1 | 5.16 | 0.0240 | 0.866 |
| Neuronal plasma membrane | Damaging/mac1 | 20/11 | 2.34 | 0.0244 | 0.875 |
| Neuronal plasma membrane | Damaging/maf01 | 29/23 | 1.63 | 0.0279 | 0.907 |
| Neuronal plasma membrane | Damaging/maf05 | 38/34 | 1.44 | 0.0390 | 0.954 |
| Neuronal Golgi | Damaging/mac1 | 11/9 | 1.58 | 0.0421 | 0.966 |
| MDD GWAS (P < 1 × 10−4) | Lof/mac1 | 8/4 | 2.58 | 0.0495 | 0.979 |
| Neuronal ARC | Damaging/maf05 | 46/40 | 1.48 | 0.0499 | 0.981 |
Abbreviations: GWAS, genome-wide association studies; MDD, major depressive disorder; OR, odds ratio; PSD, postsynaptic density.