Table 4.
Sensitivity and specificity of the components of the LFT in determining liver mortality and morbidity from the ALFIE study
| LFT | Performance measure | All deaths | Liver death | Liver disease | |||
|---|---|---|---|---|---|---|---|
| 1 year | 5 years | 1 year | 5 years | 1 year | 5 years | ||
| ALP | Sensitivity (%) | 17.4 | 11.2 | 48.8 | 37.6 | 42.5 | 32.1 |
| Specificity (%) | 89.8 | 89.7 | 89.6 | 89.6 | 89.7 | 89.8 | |
| PPV (%) | 4.9 | 9.7 | 0.2 | 0.5 | 1.5 | 2.5 | |
| NPV (%) | 97.3 | 91.0 | 99.9 | 99.9 | 99.8 | 99.4 | |
| Albumin | Sensitivity (%) | 20.4 | 11.4 | 26.8 | 19.2 | 15.0 | 6.6 |
| Specificity (%) | 99.8 | 98.9 | 98.0 | 98.0 | 98.0 | 98.0 | |
| PPV (%) | 29.4 | 50.8 | 0.6 | 1.2 | 2.6 | 3.5 | |
| NPV (%) | 98.0 | 91.8 | 99.9 | 99.9 | 99.7 | 99.0 | |
| Transaminase | Sensitivity (%) | 11.5 | 9.5 | 37.5 | 40,2 | 42.1 | 35.8 |
| Specificity (%) | 93.2 | 93.3 | 93.1 | 93.1 | 93.2 | 93.3 | |
| PPV (%) | 4.5 | 11.0 | 0.2 | 0.7 | 2.2 | 3.9 | |
| NPV (%) | 97.3 | 92.0 | 99.9 | 99.9 | 99.8 | 99.5 | |
| GGT | Sensitivity (%) | 37.1 | 27.4 | 76.9 | 71.4 | 72.4 | 61.9 |
| Specificity (%) | 85.3 | 85.7 | 84.6 | 84.7 | 85.1 | 85.4 | |
| PPV (%) | 7.4 | 15.2 | 0.4 | 1.0 | 3.1 | 5.2 | |
| NPV (%) | 97.5 | 91.2 | 99.9 | 99.9 | 99.8 | 99.4 | |
| Bilirubin | Sensitivity (%) | 10.5 | 8.5 | 35.9 | 24.8 | 16.8 | 14.9 |
| Specificity (%) | 93.0 | 93.1 | 92.9 | 92.9 | 92.9 | 93.0 | |
| PPV (%) | 4.3 | 11.0 | 0.2 | 0.5 | 0.9 | 1.7 | |
| NPV (%) | 97.2 | 91.0 | 99.9 | 99.9 | 99.7 | 99.2 | |