Table 2.
Serum concentration of IGF-binding proteins in ABN controls and T1D patients.
| Protein | ABN (n = 665) | T1D_NoC (n = 453) | 1Comp (n = 78) | 2Comp (n = 28) | 3Comp (n = 25) |
|---|---|---|---|---|---|
| A. Discovery dataset | |||||
| IGFBP1 | 867 (350–2175) | 1090 (554–2237) | 1361 (649–3690) | 2226 (1309–4813) | 2272.4 (1590–3376) |
| (pg/ml) | 1.25 (2.4 × 10−3) | 1.57 (2.0 × 10−3) | 2.55 (7.0 × 10−4) | 2.62 (1.4 × 10−7) | |
| IGFBP2 | 4.66 (1.92–11.29) | 6.50 (2.83–16.8) | 13.6 (5.8–28.2) | 25.8 (12.0–56.7) | 30.1 (11.5–52.4) |
| (ng/ml) | 1.40 (5.6 × 10−4) | 2.91 (1.4 × 10−9) | 5.53 (9.6 × 10−7) | 6.48 (1.5 × 10−9) | |
| IGFBP3 | 15.8 (12.2–20.6) | 15.2 (11.6–20.4) | 12.1.(9.4–156) | 12.5 (8.9–18.5) | 13.5 (10.1–20.3.) |
| (μg/ml) | 0.97 (0.24) | 0.77 (1.4 × 10−6) | 0.79 (0.031) | 0.86 (0.15) | |
| IGFBP6 | 61.8 (45.5–84.4) | 67.2 (50.1–92.0) | 95.7 (75.5–122.3) | 111.4 (75.3–143.7) | 146 (104–206) |
| (ng/ml) | 1.09 (2.6 × 10−3) | 1.55 (1.3 × 10−14) | 1.80 (7.5 × 10−6) | 2.36 (1.5 × 10−9) | |
| IGFBP7 | 86.8 (71.1 – 108.4) | 78.3 (63.53–99.8) | 87.43 (67.3–108.7) | 91.8 (69.8–113.4) | 109.1 (75.1–139.4) |
| (ng/ml) | 0.91 (2.6 × 10−5) | 1.01 (0.87) | 1.06 (0.56) | 1.26 (0.023) | |
| Protein | ABN (n = 1328) | T1D_NoC (n = 830) | 1Comp (n = 142) | 2Comp (n = 62) | 3Comp (n = 51) |
| B. Confirmation dataset | |||||
| IGFBP1 | 861 (315–2699) | 1152 (528–2913) | 1418 (604–2911) | 1618 (1024–3325) | 2120 (1069–4709) |
| (pg/ml) | 1.34 (4.6 × 10−7) | 1.65 (7.7 × 10−7) | 1.88 (2.7 × 10−5) | 2.45 (2.6 × 10−7) | |
| IGFBP2 | 4.2 (1.65–10.0) | 8.06 (3.62–17.6) | 16.1 (7.80–36.4) | 23.4 (9.21–57.0) | 28.3 (12.7–66.7) |
| (ng/ml) | 1.92 (1.2 × 10−34) | 3.84 (2.6 × 10−27) | 5.59 (7.4 × 10−15) | 6.75 (1.5 × 10−14) | |
| IGFBP3 | 14.4 (12.9–18.5) | 13.5 (11.9–17.4) | 10.9 (10.4–15.0) | 12.8 (11.1–15.6) | 11.4 (8.8–15.3) |
| (μg/ml) | 0.94 (0.031) | 0.76 (2.6 × 10−4) | 0.89 (0.054) | 0.79 (8.1 × 10−4) | |
| IGFBP6 | 60.6 (44.6–86.9) | 68.6 (52.0–96.2) | 94.4 (74.3–128.4) | 94.4 (68.0–139.4) | 131.6 (86.8–193.4) |
| (ng/ml) | 1.14 (1.2 × 10−7) | 1.56 (1.5 × 10−15) | 1.56 (1.9 × 10−6) | 2.17 (2.2 × 10−13) | |
First row: mean (25th–75th percentile); second row: fold change vs. ABN (p-value).
ABN, antibody negative controls; T1D_NoC, T1D, no complications; 1Comp, T1D any complication; 2Comp, T1D with 2 complications; 3Comp, T1D with ≥3 complications.