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. 2016 Jan 29;7:9. doi: 10.3389/fphys.2016.00009

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Copyright © 2016 Baker Bechmann, Rotoli, Morales, Maeso, García, Ávila, Mobasheri and Martín-Vasallo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunolocalization of the Na,K-ATPase α1 and α3 subunit isoforms in normal colon and colorectal cancer (CRC) (A,C) α1 immunostaining in baso-lateral side of polarized epithelial cells in healthy colonic mucosae, black arrow. g, colonic gland (Lieberkühn crypts); mm, muscularis mucosae; lm, lamina propia mucosae. (B,D) peri-nuclear labeling for the α1 isoform in tumor cells. T, tumor; L, lumina; m, mesenchymal tissue. (E) α3 immunostaining in plasma membrane of healthy colon epithelial tissue. (F) α3 expressed peri-nuclearly in CRC tumor (arrows). (G) α3 immunostaining in tumor cells (T) surrounded by immune cells (arrows). (H) Endothelial cells expressing the α3 isoform in a peri-nuclear location (arrows).