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. 2016 Jan 29;7:9. doi: 10.3389/fphys.2016.00009

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Copyright © 2016 Baker Bechmann, Rotoli, Morales, Maeso, García, Ávila, Mobasheri and Martín-Vasallo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunolocalization of the Na,K-ATPase β1 and β2 isoforms in normal colon and CRC. (A,B) β1 is mainly located at the baso-lateral side of polarized epithelial cells from the normal colonic mucosae (arrows in B). (C) β1 is located in the cytosol of tumor cells (arrows). (D) β1 is located at the cell membrane of tumor cells (arrows). (E) Cells from the myenteric plexus (MyP) at the muscularis propia (mp) express β1. (F) β1 isoform is mainly located in or near the cytoplasmic membrane of the neurons and/or glia; a neuron nucleus with visible nucleolus is indicated using an arrow. g, colonic gland (Lieberkühn crypts); lm: lamina propia mucosae. (G) Selected cells from the connective tissue of the mucosae express the β2 isoform (arrows). (H) β2 is mainly located at the baso-lateral side of polarized epithelial cells from the normal colon mucosae (arrows). (I) β2 was not detected in tumor cells from adenocarcinomatous glands (T); however, some stroma (S) cells express β2 (arrows). (J) Possible leukocytes of the stroma expressing β2 (arrows). (K) Cells from the myenteric plexus (MyP) at the muscularis propia (mp) express β2. (L) β2 isoform is mainly located at the soma of glia cells (arrows).