Table 3.
Possible cell-specific Na, K-ATPase isozymes present in normal colon, colorectal cancer, normal liver, and metastasized liver.
| α1β1 | α1β2 | α3β1 | α3β2 | |
|---|---|---|---|---|
| NORMAL COLON | ||||
| Epithelial cells (Mucosae) | +++ | + | +++ | + |
| Mesenchymal cells (Submucosae) | + | + | + | + |
| Smooth muscle cells (Muscularis mucosae) | ? | ? | ? | ? |
| Neurons (Myenteric plexus) | ? | ? | +++ | ? |
| Glia cells (Myenteric plexus) | ? | ? | ? | ? |
| Smooth muscle cells (Muscularis propia) | – | ? | – | +++ |
| COLORECTAL CANCER | ||||
| Tumor cells | +++ | – | +++ | – |
| Mesenchymal cells (Not immune system cells) | – | + | – | +++ |
| Immune system cells | ? | ? | ? | ? |
| Endothelial cells | – | ? | – | ? |
| Epithelial cells (Mucosae) | +++ | – | +++ | – |
| NORMAL LIVER | ||||
| Hepatocytes | +++ | + | – | – |
| Ephitelial cells (Bile duct) | +++ | +++ | – | – |
| Endothelial cells | – | – | – | – |
| Mesenchymal cells (Connective tissue) | – | – | – | – |
| METASTIZED LIVER | ||||
| Tumor cells | +++ | – | +++ | – |
| Hepatocytes | ? | – | ? | – |
| Epithelial cells (Bile duct) | ? | ? | ? | ? |
| Mesenchymal cells (Connective tissue) | – | – | – | – |
| Immune system cells | – | – | ? | ? |
+++, Indicates a possible high level of the isozyme; +, indicates a possible low presence of the isozyme; –, indicates no possibility; and ?, indicates indeterminate staining, according to our observations.