| Histological diagnosis group |
| Cardiac sarcoidosis is confirmed when endomyocardial biopsy specimens demonstrate non-caseating epithelioid granulomas with histological or clinical diagnosis of extra-cardiac sarcoidosis |
| Clinical diagnosis group |
| Although endomyocardial biopsy specimens do not demonstrate non-caseating epithelioid granulomas, extra-cardiac sarcoidosis is diagnosed histologically or clinically and satisfies the following condition and more than one in six basic diagnostic criteria: |
| (I) Two or more of the four major criteria are satisfied |
| (II) One in four of the major criteria and two or more of the five minor criteria are satisfied |
| Major criteria |
| Advanced AV block |
| Basal thinning of the interventricular septum |
| Positive Gallium-67 uptake in the heart |
| Depressed left ventricular ejection fraction <50% |
| Minor criteria |
| Abnormal ECG findings: ventricular arrhythmias (VT or multifocal or frequent PVCs), complete RBBB, axis deviation, or abnormal Q waves |
| Abnormal ECHO: wall motion abnormality or morphological abnormality (aneurysm or wall thickening or ventricular dilation) |
| Perfusion defects on nuclear imaging: thallium-201, technetium 99m SPECT |
| Delayed gadolinium enhancement on CMR |
| Interstitial fibrosis or monocyte infiltration on cardiac biopsy |
