. 2016 Jan 1;193(1):23–30. doi: 10.1164/rccm.201505-0870OC

Table 3.

Ventilatory Function Characteristics in WHEASE 2014 by 1964 and 2001 Wheezing Phenotype Categories

	Total (n = 330)^*	1964 Definitions				2001 Definitions (Including AOW)
	Total (n = 330)^*	CA^† (n = 38)	WB/VAW^‡ (n = 53)	Controls^§ (n = 239)	P Value	AOW (n = 57)	Controls^\|\| (n = 182)	P Value
FEV₁, %pred, mean (95%CI)	95.5 (93.4–97.3)	81.3 (72.8–89.9)	97.3 (93.2–101.4)	97.1 (95.1–99.2)	<0.001^¶	92.5 (88.0–97.0)	98.6 (96.3–101)	<0.001^¶
FVC, %pred, mean (95%CI)	107 (106–109)	100 (94.4–106)	108 (104–112)	108 (106–110)	0.014^¶	107 (102–112)	108 (106–110)	0.025^¶
FEF_25–75%,%pred, mean (95%CI)	76.1 (72.2–79.9)	55.9 (43.7–68.1)	83.1 (72.4–93.8)	77.8 (73.5–82.1)	0.001^¶	67.3 (59.1–75.5)	81.1 (76.1–86.1)	<0.001^¶
FEV₁/FVC, mean (95%CI)	0.69 (0.68–0.70)	0.62 (0.58–0.66)	0.71 (0.68–0.73)	0.70 (0.69–0.71)	<0.001^¶	0.68 (0.66–0.70)	0.71 (0.70–0.73)	<0.001^¶
FEV₁/FVC < 0.7, n (%)	143 (43.3)	27 (71.1)	23 (43.4)	93 (38.9)	0.001^**	29 (50.9)	64 (35.2)	<0.001^**
FEV₁/FVC < LLN, n (%)	100 (30.3)	23 (60.5)	14 (26.4)	63 (26.4)	<0.001^**	21 (36.8)	37 (20.3)	<0.001^**

Definition of abbreviations: %pred = percentage predicted; AOW = adult-onset wheeze; CI = confidence interval; LLN = lower 95% confidence limit of the internationally agreed predictive equations for normality; WB/VBW = wheezy bronchitis/virus-associated wheeze; WHEASE = What Happens Eventually to Asthmatic children: Sociologically and Epidemiologically.

Questionnaire data in 328 subjects and physiological measurements in 329 subjects.

^{^†}

Childhood asthma.

^{^‡}

Childhood WB/VAW.

^{^§}

Childhood controls.

^{^||}

Adult controls. When applying the 2001 definitions, spirometry at ages 60 to 65 years is compared only between individuals with AOW (i.e., who were defined as controls in 1964) and subjects who never developed respiratory symptoms.

^{^¶}

Difference across childhood groups: one-way analysis of variance.

^**

Difference across childhood groups: χ².