Table 5.
Associations between 1964 and 2001 Wheezing Groups and Chronic Obstructive Pulmonary Disease at Ages 35 to 65 Years: Discrete Time Logistic Model Using All Data Collected between 1989 and 2014
| FEV1/FVC < 0.7 [Adjusted OR*(95% CI)] | FEV1/FVC < LLN [Adjusted OR*(95% CI)] | |
|---|---|---|
| 1964 wheeze groups | ||
| Childhood controls, n = 820 | 1.00 | 1.00 |
| Childhood asthma, n = 135 | 5.79 (3.44–9.73) | 5.68 (3.41–9.44) |
| Childhood WB/VAW, n = 189 | 1.65 (1.04–2.61) | 1.56 (0.94–2.59) |
| 2001 wheeze groups | ||
| Childhood controls, n = 637 | 1.00 | 1.00 |
| Childhood asthma, n = 135 | 6.37 (3.73– 10.9) | 5.11 (2.93–8.92) |
| Childhood WB/VAW, n = 189 | 1.81 (1.12–2.91) | 1.48 (0.86–2.57) |
| Adult-onset wheeze (16–45 yr), n = 183 | 1.45 (0.91–2.32) | 1.86 (1.11–3.13) |
Definition of abbreviations: CI = confidence interval; LLN = lower 95% confidence limit of the internationally agreed predictive equations for normality; OR = odds ratio; WB/VBW = wheezy bronchitis/virus-associated wheeze.
*
Adjusted for sex, age, history of ever smoking, and Scottish Index of Multiple Deprivation in 2014.