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. 2015 Nov 15;192(10):1191–1199. doi: 10.1164/rccm.201503-0609OC

Figure 1.

Figure 1.

Murine model of carbon monoxide (CO) poisoning. (A) Inhaled and exhaled CO concentrations during poisoning (0–60 min) with 400 ppm CO and treatment (60–160 min) by breathing either air or 100% O2 (n = 5 per group). The red shaded area between the inhaled and exhaled CO curves (differential areas under the curves) during the poisoning period reflects the quantity of absorbed CO. The green and blue shaded regions beneath the exhaled CO concentration curves (areas under the curves) during the treatment period reflect the amount of CO eliminated while breathing either air or 100% O2, respectively. (A, inset) In the first 15 minutes of the treatment period, the quantity (ml/kg) of exhaled CO of mice breathing 100% O2 was significantly greater as compared with mice breathing air (*P < 0.001; Student’s t test). (B) Arterial blood carboxyhemoglobin (COHb) levels during poisoning with 400 ppm CO (0–60 min) and during treatment by breathing either air or 100% O2. Treatment with 100% O2 induced a more rapid decrease in arterial COHb levels as compared with air breathing and (B, inset) COHb half-life (COHb-t1/2) was significantly shorter (*P < 0.001; Student’s t test). All data represent mean ± SD.