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. 2015 Nov 15;192(10):1191–1199. doi: 10.1164/rccm.201503-0609OC

Figure 4.

Figure 4.

Phototherapy decreases carbon monoxide (CO) uptake during poisoning. Mice breathed 400 ppm CO for 1 hour with (n = 5) or without (n = 6) simultaneous phototherapy at 628 nm. (A) Inhaled and exhaled CO concentrations during the poisoning. Starting 4 minutes after initiation of CO exposure, exhaled CO concentration was higher in phototherapy-treated mice as compared with control animals (*P < 0.05 vs. exhaled CO control animals; P interaction <0.001; two-way analysis of variance for repeated measurements). The red shaded area between the inhaled and exhaled CO concentration curves reflects the amount of CO absorbed by mice concomitantly treated with phototherapy. The yellow shaded area reflects the additional amount of CO absorbed by control mice. (B) Cumulative CO uptake during poisoning calculated from the red and yellow areas in A. *P < 0.001, Student’s t test. (C) Arterial blood carboxyhemoglobin (COHb) levels at 20, 40, and 60 minutes were significantly lower in phototherapy-treated mice than in control animals (*P < 0.001 vs. control animals; P interaction <0.001; two-way analysis of variance for repeated measurements). All data represent mean ± SD.