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. 2015 Nov 15;192(10):1191–1199. doi: 10.1164/rccm.201503-0609OC

Figure 5.

Figure 5.

Phototherapy improves survival in ongoing carbon monoxide (CO) poisoning. (A) Survival rate of mice breathing 2,000 ppm CO in air for 1 hour with or without simultaneous phototherapy at 532 nm (n = 6 per group). All control mice died within 30 minutes of commencing CO exposure. In contrast, five of six phototherapy-treated mice breathing 2,000 ppm CO survived for 60 minutes. *P < 0.001, phototherapy versus control animals, log-rank test. (B) Arterial carboxyhemoglobin (COHb) levels during poisoning were significantly lower in phototherapy-treated mice compared with control animals (*P < 0.001; P interaction <0.001; two-way analysis of variance [ANOVA] for repeated measurements). (C) Systolic arterial pressure (SAP; mean ± SEM), commencing at minute 21 of exposure, decreased in control mice, whereas SAP remained constant in phototherapy-treated mice (*P < 0.001; P interaction <0.001; two-way ANOVA for repeated measurements). (D) Heart rate (HR, mean ± SEM), commencing from minute 17, decreased in control animals but not in phototherapy-treated mice (*P < 0.001; P interaction <0.001; two-way ANOVA for repeated measurements). (E) Blood lactate levels during poisoning were significantly lower in mice treated with lung phototherapy compared with untreated mice (*P < 0.001; †P = 0.05, P interaction <0.001; two-way ANOVA for repeated measurements at time 0, 10, and 20 min). All data represent mean ± SD except for SAP and HR.