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Metformin and PP242 reduced tumor burden in xenograft model. A: Mice were treated in 4 different groups. (Control: PBS, metformin: 350 mg/Kg, PP242: 5 mg/Kg in 30% PEG 400, combined: metformin 350 mg/Kg + PP242: 5 mg/Kg). Tumor size was measured every week and the volume was calculated by 0.5 × lengh × width2. B: Gross tumors removed from animals after 6 weeks treatment. C: Tumor weight valued instantly after dissection from euthanized animals. **P < 0.01.
