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Metformin reduced human salivary gland cell proliferation in vivo. A. H&E staining. Lower magnification (4 ×) and higher magnification (40 ×) images were captured in PBS and metformin treated group. The yellow arrow indicates the boundary between tumor cells and necrotic cells. B. IHC for Ki67 on tumor sections from both groups. C. Values of Ki67-positive ratio based on 40 × magnification images.
