Morphologic appearance of sciatic nerve 2 weeks after extracorporeal shock wave (ECSW) treatment (n=10). A-D. Gross anatomical study demonstrated that the sciatic nerve in AMC + SW, DM and DM + SW groups was grossly intact comparable to that in the AMC group. These findings suggest that the energy dosage of ECSW did not affect the anatomical integrity of sciatic nerve. E-G. Illustrating the microscopic (400x) histopathological finding of sciatic nerve among the three groups of the animals. H. Analytic results of number of nuclei (yellow arrows), * vs. other group with different symbols, p<0.001. I. Analytic results of number of vacuole (red arrows), * vs. other group with different symbols, p<0.0001. The scale bars in right lower corner represent 20 µm. All statistical analyses using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (*, †) indicate significance (at 0.05 level). AMC=aged matched control; DM=diabetes mellitus; SW=shock wave.