Figure 1.

Effect of Dvl treatment on renal function of IR-induced AKI rats. Renal hemodynamics evaluation through determination of glomerular filtration rate (GFR), as assessed by inulin clearance (A) and renal plasma flow (RPF), as assessed by PAH clearance (B), as well as renal blood flow (C) and vascular resistance (D) in sham and IR animals treated with vehicle (white bars) or Dvl (cross-hatched bars). GFR, RPF and renal blood flow (RBF) were significantly decreased in vehicle-treated IR animals. Dvl intravenous injection prior to IR resulted in an amelioration of these parameters. Renal vascular resistance (RVR) was increased in the IR VH group, and Dvl treatment normalized RVR. N=6-7. Values are means ± SEMs. *p<0.05 vs. sham group; &p<0.05 vs. IR VH; #p<0.05 vs. sham VH. Two-way ANOVA followed by Tukey’s post hoc test.