Figure 2.

Effect of Dvl treatment on plasma urea and kidney morphology. A. Renal function evaluation using plasma levels of urea in sham and IR-induced AKI animals receiving vehicle (white bars) or Dvl (cross-hatched bars). Note a significant increase in uremia in IR vehicle-treated animals, which was prevented by Dvl administration. N=5-6. Values are means ± SEM. *p<0.05 vs. sham group; &p<0.05 vs. IR VH. Two-way ANOVA followed by Tukey’s post hoc test. B. Representative photomicrographs of kidney histology in sham (left) and rats submitted to ischemia-reperfusion (right) treated with vehicle (top) or Dvl (bottom). Dvl reduced renal damage following renal IR injury. Normal morphology in sham vehicle and in sham Dvl rats. Vehicle-treated rats following IR injury presented severe tubular damage, including tubular dilation (#), proteinaceous cast (*), tubular necrosis (§) and loss of brush border (arrow). Treatment with Dvl reduced the extent of tubular damage. Original magnification × 100.