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. 2015 Dec 15;7(12):2775–2785.

Figure 1.

Figure 1

Dysregulation expression of miR-451, Ywhaz and FoxO3 in human CRC tissues. A. miR-451 expression was down-regulated in CRC tissues (Duke A: n=10, Duke B: n=16, Duke C: n=12, Duke D: n=8) and CRC cell lines (HT-29 cells and HCT-116 cells) when compare with adjacent normal tissues (n=46) (qRT-PCR; normalized by U6). B. When compared with normal colon tissues (n=46), Ywhaz mRNA expression was up-regulated in CRC tissues significantly, but FoxO3 mRNA expression decreased (qRT-PCR; normalized to GAPDH). C. Immunohistochemistry showed Ywhaz expression in the cytoplasm and membrane and FoxO3 expression in the nucleus were up-regulated and down-regulated, respectively in CRC tissues. *P<0.05, **P<0.01 vs. control. All experiments were repeated three times.